Surveillance for Unexplained Deaths and Critical Illnesses
نویسندگان
چکیده
Population-based surveillance for unexplained death and critical illness possibly due to infectious causes (UNEX) was conducted in four U.S. Emerging Infections Program sites (population 7.7 million) from May 1, 1995, to December 31, 1998, to define the incidence, epidemiologic features, and etiology of this syndrome. A case was defined as death or critical illness in a hospitalized, previously healthy person, 1 to 49 years of age, with infection hallmarks but no cause identified after routine testing. A total of 137 cases were identified (incidence rate 0.5 per 100,000 per year). Patients' median age was 20 years, 72 (53%) were female, 112 (82%) were white, and 41 (30%) died. The most common clinical presentations were neurologic (29%), respiratory (27%), and cardiac (21%). Infectious causes were identified for 34 cases (28% of the 122 cases with clinical specimens); 23 (68%) were diagnosed by reference serologic tests, and 11 (32%) by polymerase chain reaction-based methods. The UNEX network model would improve U.S. diagnostic capacities and preparedness for emerging infections.
منابع مشابه
Unexplained Deaths and Critical Illnesses of Suspected Infectious Cause, Taiwan, 2000–2005
We report 5 years' surveillance data from the Taiwan Centers for Disease Control on unexplained deaths and critical illnesses suspected of being caused by infection. A total of 130 cases were reported; the incidence rate was 0.12 per 100,000 person-years; and infectious causes were identified for 81 cases (62%).
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Rana A. Hajjeh,* David Relman,† Paul R. Cieslak,‡ Andre N. Sofair,§ Douglas Passaro,¶ Jennifer Flood,¶ James Johnson,# Jill K. Hacker,¶ Wun-Ju Shieh,* R. Michael Hendry,¶ Simo Nikkari,† Stephen Ladd-Wilson,‡ James Hadler,§ Jean Rainbow,# Jordan W. Tappero,* Christopher W. Woods,* Laura Conn,* Sarah Reagan,* Sherif Zaki,* and Bradley A. Perkins,* for the Unexplained Deaths and Critical Illness W...
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We examined the need to improve our ability to explain the unexplained in clinical infectious diseases, primarily through improvements in diagnostic technology. Part of the motivation for this effort came from an Emerging Infectious Disease Program (funded by the National Center for Infectious Diseases, Centers for Disease Control and Prevention [CDC]) to conduct surveillance for unexplained de...
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عنوان ژورنال:
دوره 8 شماره
صفحات -
تاریخ انتشار 2002